Experts at the University of Pennsylvania, USA, have recreated wasp venom and developed new protein, effective in treating bacterial infections.
The team of researchers at the Perelman School of Medicine (University of Pennsylvania, USA) has just announced the results of the new sterilization fecal reconstruction work from proteins in wasps’ venom. They hope this result will be a prerequisite for new antibacterial drugs (especially sepsis, tuberculosis), in addition to existing antibiotics.
The research of the authors group in the US is published in the journal Proceedings of the National Academy of Sciences. The team said they modified a powerful protein in Asian wasps – Vespula lewisii – for this study.
The changes help increase the ability to kill cells in the molecule, significantly reduce the effect of bee venom to human cells. When tested in rats, the regenerated protein from bee venom showed significant cell protection from endemic bacterial infections.
Today, the demand for treatments for bacterial infections increases. The reason is bacteria tend to mutate and have strong drug resistance. The US Centers for Disease Control and Prevention estimates that each year 3 million people are infected with drug-resistant bacteria. In which, more than 35,000 people from vong.
Globally, the problem of resistant bacteria is even worse. Septicemia caused widespread vong. It is estimated that in 2017, 20% of all cholera cases in the world came from this disease.
Professor De la Fuente and his team began research with mastoparan-L peptides. This is the main ingredient in the Vespula lewisii wasp venom. It is not harmful to humans but contains many nutrients. Only a small amount of Vespula lewisii bee venom can also destroy red blood cells, causing allergies and severe inflammation.
In many people, when Vespula lewisii is sick, the victim will suffer anaphylaxis, hypotension, and difficulty breathing.
The authors performed experiments on mice infected with E. coli or Staphylococcus aureus strains. These are the two types of bacteria that can cause death.
The rats were treated with antimicrobial peptides regenerated from bee venom and showed more positive results than the rest. It also helps to create a stronger shield against bacterial invasion. At the same time, peptides reduce the immune response when attacked by bacteria.
Researchers will continue to study the peptide’s concentration in clinical trials in humans. The new discovery promises to provide a cure for the high rates of bacterial diseases.